Precision or personalized medicine is essentially the use of the information from a person’s genotype to select the most appropriate therapy for a disease or condition. The complete characterization of the human genome was completed in 2007 and today, the cost of genotyping an individual has come down to under $1000. It will take time, however, for our health infrastructure and processes to evolve to make personalized medicine available to all. This section collects reports, articles and case studies on the policy challenges that must be overcome to realize the benefits of personalized medicine.